(RS)-MCPG

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(RS)-MCPG

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

146669-29-6

包装与价格：

包装	价格(元)
10 mM * 1 mL in DMSO	电议
5mg	电议
10mg	电议
25mg	电议
50mg	电议
100mg	电议
200mg	电议
500mg	电议

产品名称

alpha-MCPG

产品介绍

(RS)-MCPG (alpha-MCPG) 是一种竞争性和选择性 I/II 组代谢型谷氨酸受体 (mGluR) 拮抗剂。(RS)-MCPG 阻断 TBS 诱导的幼年和新生大鼠海马神经元的转变。

生物活性

(RS)-MCPG (alpha-MCPG) is a competitive and selective group I/group IImetabotropic glutamate receptor (mGluR)antagonist. (RS)-MCPG blocks theta-burst stimulation (TBS)-induced shifts in both juvenile and neonatal rat hippocampal neurons^[1]^[2].

IC₅₀& Target

group I/group II mGluR^[1]

体外研究
(In Vitro)

MCPG can block group I (mGluR1 and mGluR5) and group II receptors (mGluR2 and mGluR3)^[2].

体内研究
(In Vivo)

(RS)-MCPG (alpha-MCPG; 500 μM) blocks the TBS-induced shifts in EGABA in either juvenile or neonatal neurons^[1].
Pretreatment with the low dose of (RS)-MCPG (25 nM; i.c.; daily; 5 days) significantly attenuates amphetamine-induced locomotor activity in 10-day-old male and female rats of Sprague-Dawley descent^[2].

分子量

209.20

性状

Solid

Formula

C₁₀H₁₁NO₄

CAS 号

146669-29-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

1M NaOH : 100 mg/mL(478.01 mM;ultrasonic and adjust pH to 10 with NaOH)

DMSO : 6 mg/mL(28.68 mM;Need ultrasonic and warming)

H₂O :< 0.1 mg/mL (ultrasonic;heat to 80℃)(insoluble)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	4.7801 mL	23.9006 mL	47.8011 mL
5 mM	0.9560 mL	4.7801 mL	9.5602 mL
10 mM	0.4780 mL	2.3901 mL	4.7801 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。