(S)-MCPG ((+)-MCPG) is a potentgroup I/II metabotropic glutamate receptor (mGluRs)antagonist and the active isomer of (RS)-MCPG (HY-100371)^[1]. (S)-MCPG can be used for the study of the function of mGluRs in spatial learning^[2].

(S)-MCPG (100 μM) has no detectable effects on basal spine formation or elimination mechanisms in WT slice cultures. (S)-MCPG prevents the increase in spine turnover triggered by TBS and interferes with the mechanisms of activity-dependent spine stabilization in Hippocampal slice cultures^[1].

MCPG (intraventricular injection; 20 μg) treated rat are slower to learn the task and takes longer to reach the platform than vehicle injected animals. On days 2 and 3, MCPG rats has a significant longer escape latency and the measure of search error is significantly longer on each of the first 3 days. On day 4, MCPG-treated animals reaches the same level of performance as control animals in Morris water maze^[2].

209.20

Solid

C₁₀H₁₁NO₄

150145-89-4

Room temperature in continental US; may vary elsewhere.

DMSO : 1 mg/mL(4.78 mM;Need ultrasonic)

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