E4CPG

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E4CPG

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

170846-89-6

包装与价格：

包装	价格(元)
5mg	电议
10mg	电议
25mg	电议
50mg	电议
100mg	电议
200mg	电议
500mg	电议

产品名称

(RS)-ECPG

产品介绍

E4CPG ((RS)-ECPG) 是一种 Group I/Group II 代谢型谷氨酸受体 (Group I/Group II metabotropic glutamate receptor) 的拮抗剂。E4CPG 可以抑制单突触后机制中突触后电流 (IPSC) 增强的成对脉冲比。

生物活性

E4CPG ((RS)-ECPG) is aGroup I/Group II metabotropic glutamate receptor (mGluR)antagonist. E4CPG can inhibit the paired-pulse ratio of monosynaptic inhibitory postsynaptic currents (IPSC) potentiation^[1]^[2].

IC₅₀& Target^[1]

mGluR

体外研究
(In Vitro)

E4CPG acts at rat cortical mGluR with the K_Bvalue of 0.367 mM^[3].

体内研究
(In Vivo)

E4CPG (3-30 nmol/site (i.t.), 1-10 μmol/paw (i.pl.), and 1-10 nmol/site (i.c.v.)) significantly inhibits the nociception induced by the Glutamate-injection (i.pl.; 30 μmol/paw), and the maximal inhibition values for the antinociceptive action of E4CPG in Glutamate-induced nociception are 48% (i.pl.), 49% (i.t.) and 40% (i.c.v.)^[4].
E4CPG (35 nM/3.5 μL, i.c.v.) completely blocks long-term depression (LTD) induced by the group I mGluR agonist Dihydroxyphenylglycine (DHPG, 100 nM/5 μL, i.c.v.) in male Sprague-Dawley rats^[5].

Animal Model:	Male Swiss mice (25-35 g)^[4]
Dosage:	3-30 nmol/site (i.t.), 1-10 μmol/paw (i.pl.) and 1-10 nmol/ site (i.c.v.)
Administration:	Single injection
Result:	The maximal inhibition values for the antinociceptive action of E4CPG in glutamate-induced nociception were 48% (i.pl.), 49% (i.t.) and 40% (i.c.v.).

Animal Model:	Male Sprague-Dawley rats^[5]
Dosage:	35 nM/3.5 μL
Administration:	Single injection, i.c.v.
Result:	Completely blocked LTD induced by the group I mGluR agonist dihydroxyphenylglycine (DHPG).

分子量

223.23

性状

Solid

Formula

C₁₁H₁₃NO₄

CAS 号

170846-89-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : 10 mg/mL(44.80 mM;ultrasonic and adjust pH to 12 with NaOH)

H₂O : 1 mg/mL(4.48 mM;ultrasonic and warming and heat to 80℃)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	4.4797 mL	22.3984 mL	44.7968 mL
5 mM	0.8959 mL	4.4797 mL	8.9594 mL
10 mM	0.4480 mL	2.2398 mL	4.4797 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。