VU-1545

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VU-1545

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

890764-63-3

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

VU-1545 是一种代谢型谷氨酸受体 5 正变构调节剂 (mGluR5 PAM)，K_i为 156 nM，EC₅₀为 9.6 nM。

生物活性

VU-1545 is a metabotropic glutamate receptor 5 positive allosteric modulator (mGluR5PAM) with aK_iof 156 nM and anEC₅₀of 9.6 nM^[1].

IC₅₀& Target

mGluR5

156 nM (Ki)

mGluR5

9.6 nM (EC₅₀)

体外研究
(In Vitro)

VU-1545 (10 and 100 μM) promotes AKT activation. VU-1545 at the concentrations of 0.1 and 1.0 μM efficiently promots Akt activation above basal levels^[2].

Western Blot Analysis^[2]

Cell Line:	Neuronal cells
Concentration:	10 and 100 μM
Incubation Time:	5 minutes
Result:	Promoted Akt phosphorylation as efficiently at the concentration of 10.0 μM as at the concentration of 100.0 μM.

分子量

402.38

Formula

C₂₂H₁₅FN₄O₃

CAS 号

890764-63-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.