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Neurokinin B
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:86933-75-7
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
神经激肽 B
产品介绍
Neurokinin B 属于速激肽家族。Neurokinin结合到一系列 G 蛋白偶联受体 (GPCR)-包括神经激肽受体 1 (NK1R),NK2R 和 NK3R,且介导其生物学作用。
生物活性

Neurokinin B belongs to the tachykinin family ofpeptides. Neurokinin B binds a family of GPCRs-includingneurokinin receptor1 (NK1R), NK2R, and NK3R-to mediate their biological effect[1].

IC50& Target

Neurokinin receptor[1]

体外研究
(In Vitro)

Neurokinin B (NKB) belongs to the tachykinin family of peptides that initially included the neuropeptides substance P (SP), neurokinin A (NKA), and NKB and more recently, endokinins and hemokinins. Tachykinins bind a family of G-protein-coupled receptors (GPCRs)-including neurokinin receptor 1 (NK1R), NK2R, and NK3R-to mediate their biological effect[1].

分子量

1210.42

Formula

C55H79N13O14S2

CAS 号

86933-75-7

Sequence

Asp-Met-His-Asp-Phe-Phe-Val-Gly-Leu-Met-NH2

Sequence Shortening

DMHDFFVGLM-NH2

中文名称

神经激肽 B

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

H2O

Peptide Solubility and Storage Guidelines:

1.  Calculate the length of the peptide.

2.  Calculate the overall charge of the entire peptide according to the following table:

 ContentsAssign value
Acidic amino acidAsp (D), Glu (E), and the C-terminal -COOH.-1
Basic amino acidArg (R), Lys (K), His (H), and the N-terminal -NH2+1
Neutral amino acidGly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q)0

3.  Recommended solution:

Overall charge of peptideDetails
Negative (<0)1.  Try to dissolve the peptide in water first.
2.  If water fails, add NH4OH (<50 μL).
3.  If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0)1.  Try to dissolve the peptide in water first.
2.  If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.  If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0)1.  Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.  For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.