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Vapreotide
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:103222-11-3
包装与价格:
包装价格(元)
10 mM * 1 mL in Water电议
1mg电议
5mg电议
10mg电议
50mg电议
100mg电议
200mg电议

产品名称
伐普肽
RC160
BMY 41606
产品介绍
Vapreotide 是神经激肽-1 (NK1) 受体拮抗剂,其IC50值为 330 nM。
生物活性

Vapreotide is aneurokinin-1 (NK1) receptorantagonist, with anIC50of 330 nM.

IC50& Target

NK1

 

体外研究
(In Vitro)

Vapreotide attenuates the effect of SP on calcium release in a concentration-dependent manner. The concentration required for Vapreotide to completely inhibit the effect of SP is about 100 times higher than that required for the NK1R antagonist aprepitant. The effect of Vapreotide on cell proliferation is mediated primarily by SSTR2. In order to further establish the NK1R antagonist effect of Vapreotide, U373MG cells are pretreated with SSTR2 selective antagonist CYN followed by incubation with Vapreotide and SP stimulation. The results show that pretreatment with CYN does not reverse the inhibitory effect of Vapreotide on SP-stimulated IL-8 mRNA expression. Vapreotide reduces HIV-1 replication in MDM as indicated by limited HIV gag mRNA expression compared to control MDM. In addition, SP treatment (10 μM) reverses Vapreotide inhibition of HIV-1 replication in MDM. This observation indicates that the inhibition of HIV-1 replication by Vapreotide is most likely due to its interaction with NK1R[1].

Clinical Trial
分子量

1131.37

性状

Solid

Formula

C57H70N12O9S2

CAS 号

103222-11-3

Sequence

Phe-Cys-Tyr-Trp-Lys-Val-Cys-Trp-NH2 (Disulfide bridge: Cys2-Cys7)

Sequence Shortening

FCYWKVCW-NH2 (Disulfide bridge: Cys2-Cys7)

中文名称

伐普肽

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture and light

Powder-80°C2 years
-20°C1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性数据
In Vitro: 

H2O : 100 mg/mL(88.39 mM;Need ultrasonic)

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM0.8839 mL4.4194 mL8.8388 mL
5 mM0.1768 mL0.8839 mL1.7678 mL
10 mM0.0884 mL0.4419 mL0.8839 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture and light)。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。