CAS NO: | 622370-35-8 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
生物活性 | Tradipitant (VLY-686) is aneurokinin-1(NK-1) antagonist. | ||||||||||||||||
IC50& Target | NK-1[1] | ||||||||||||||||
体外研究 (In Vitro) | Results reveal that Tradipitant ([3H]-LY686017) bind to sections of guinea pig brain with a distribution similar to that previously reported for NK-1 receptors. Areas with the highest density are the accessory olfactory nucleus, anteroventral thalamic nucleus, paraventricular hypothalamic nucleus central amygdaloid nucleus (lateral) and the medial amygdaloid nucleus (anterodorsal)[1]. | ||||||||||||||||
体内研究 (In Vivo) | Autoradiography experiments reveal that intravenously administered Tradipitant ([3H]-LY686017) localizes in the guinea pig brain and has a distribution similar to that described for the NK-1 receptor using agonist or antagonist radioligands[1]. | ||||||||||||||||
Clinical Trial | |||||||||||||||||
分子量 | 587.90 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C28H16ClF6N5O | ||||||||||||||||
CAS 号 | 622370-35-8 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 100 mg/mL(170.10 mM;Need ultrasonic) 配制储备液
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