您好,欢迎来到试剂信息网! [登录] [免费注册]
试剂信息网
位置:首页 > 产品库 > Neurokinin A
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Neurokinin A
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:86933-74-6
包装与价格:
包装价格(元)
25mg电议
1mg电议
5mg电议
10mg电议
50mg电议
100mg电议

产品名称
Substance K
Neurokinin α
Neuromedin L
产品介绍
Neurokinin A (Substance K) 是速激肽家族的一种肽类神经递质,通过NK-2受体发挥作用。在人气道和胃肠道组织中作为主要的介体。
生物活性

Neurokinin A (Substance K), a peptide neurotransmitter of the tachykinin family, acts via theNK-2receptor. Neurokinin A acts as a major mediator in human airway and gastrointestinal tissues[1].

IC50& Target

NK-2 receptor[1]

体外研究
(In Vitro)

Neurokinin A (substance K) is a peptide neurotransmitter of the tachykinin family with potential as a major mediator in human airway and gastrointestinal tissues. Neurokinin A acts via the NK-2 receptor believed to be localized on smooth muscle cells and pharmacologically coupled to a GTP-binding protein. Neurokinin A is a member of a family of peptide neurotransmitters known as tachykinins. These peptides are associated with the central and peripheral nervous systems and display a wide tissue distribution. Tachykinins share the COOH-terminal structure Phe-X-Gly-Leu-Met-NH. The best known members of this family are Substance P and Neurokinin A or Substance K[1].

分子量

1133.32

性状

Solid

Formula

C50H80N14O14S

CAS 号

86933-74-6

Sequence

His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu-Met-NH2

Sequence Shortening

HKTDSFVGLM-NH2

中文名称

神经激肽 A

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture

Powder-80°C2 years
-20°C1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O

Peptide Solubility and Storage Guidelines:

1.  Calculate the length of the peptide.

2.  Calculate the overall charge of the entire peptide according to the following table:

 ContentsAssign value
Acidic amino acidAsp (D), Glu (E), and the C-terminal -COOH.-1
Basic amino acidArg (R), Lys (K), His (H), and the N-terminal -NH2+1
Neutral amino acidGly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q)0

3.  Recommended solution:

Overall charge of peptideDetails
Negative (<0)1.  Try to dissolve the peptide in water first.
2.  If water fails, add NH4OH (<50 μL).
3.  If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0)1.  Try to dissolve the peptide in water first.
2.  If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.  If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0)1.  Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.  For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.