CAS NO: | 204519-66-4 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | Talnetant (SB 223412) hydrochloride is a selective, competitive, brain-permeableNK3receptor antagonist with aKiof 1.4 nM in hNK-3-CHO cells. Talnetant hydrochloride is 100-fold more selective for hNK-3 relative to the hNK-2 receptor and has no affinity for hNK-1. Talnetant hydrochloride can be used in schizophrenia-related studies[1][2][3]. | ||||||||
体外研究 (In Vitro) | Talnetant (SB 223412) (0.1-1 μM) hydrochloride can reduce the accumulation of NKB-induced IP in U-2OS cells expressing the human NK3 receptor[3]. | ||||||||
体内研究 (In Vivo) | Talnetant (SB 223412) hydrochloride (0.5-2 mg/kg iv, 2min pretreatment) can inhibit the miosis induced by senktide (25μg, iv) in a dose-dependent manner with an ED50of 0.44mg/kg in conscious rabbits[1].
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Clinical Trial | |||||||||
分子量 | 418.92 | ||||||||
Formula | C25H23ClN2O2 | ||||||||
CAS 号 | 204519-66-4 | ||||||||
中文名称 | 盐酸他奈坦 | ||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |