CAS NO: | 75976-10-2 |
包装 | 价格(元) |
500 μg | 电议 |
1mg | 电议 |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
生物活性 | Pancreatic Polypeptide, human is a C-terminally amidated 36 amino acid peptide, which acts as aneuropeptide Y(NPY)Y4/Y5receptor agonist. | ||||||||||||||||
IC50& Target | Neuropeptide Y (NPY) Y4/Y5 receptor[1] | ||||||||||||||||
体外研究 (In Vitro) | Human pancreatic polypeptide (hPP) is one such peptide, being released postprandially from F cells of the pancreatic islets depending on caloric load, food consumption and circadian rhythm. It is a C-terminally amidated 36 amino acid peptide with a characteristic hairpin-like pancreatic polypeptide (PP)-fold and acts at the Y4 receptor to induce satiety and delay gastric emptying and motility[1]. Addition of the human pancreatic polypeptide (hPP) (10 nM-1 μM) results in a significant, dose-dependent reduction in both basal and stimulated release. Human pancreatic polypeptide (hPP) can also inhibit basal and stimulated NPY release with a pharmacological profile suggesting a role for Y4 presynaptic receptors[2]. | ||||||||||||||||
分子量 | 4181.71 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C185H287N53O54S2 | ||||||||||||||||
CAS 号 | 75976-10-2 | ||||||||||||||||
Sequence | Ala-Pro-Leu-Glu-Pro-Val-Tyr-Pro-Gly-Asp-Asn-Ala-Thr-Pro-Glu-Gln-Met-Ala-Gln-Tyr-Ala-Ala-Asp-Leu-Arg-Arg-Tyr-Ile-Asn-Met-Leu-Thr-Arg-Pro-Arg-Tyr-NH2 | ||||||||||||||||
Sequence Shortening | APLEPVYPGDNATPEQMAQYAADLRRYINMLTRPRY-NH2 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 | Sealed storage, away from moisture
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) | ||||||||||||||||
溶解性数据 | In Vitro: DMSO : 25 mg/mL(5.98 mM;Need ultrasonic) 配制储备液
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以下溶剂前显示的百
*以上所有助溶剂都可在本网站选购。 |