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β-Endorphin,human
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:61214-51-5
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
50mg电议
100mg电议

产品名称
β-内啡肽,人
产品介绍
β-Endorphin, human 是存在于垂体和下丘脑中的重要的内源性肽,为阿片样 (opioid) 受体激动剂,尤其对μ-opioid受体和δ-opioid受体的亲和性更高;β-Endorphin, human 具有缓解疼痛的功效。
生物活性

β-Endorphin, human, a prominent endogenous peptide, existing in the hypophysis cerebri and hypothalamus, is an agonist ofopioid receptor, with preferred affinity forμ-opioid receptorandδ-opioid receptor; β-Endorphin, human exhibits antinociception activity.

IC50& Target

Opioid receptor[1]

体外研究
(In Vitro)

β-Endorphin, human is an agonist of opioid receptor, with preferred affinity for μ-opioid receptor and δ-opioid receptor. β-Endorphin exhibits anti-nociception activity by stimulating ε-opioid receptor, rather than μ-, δ-, and κ-opioid receptor[1]. β-Endorphin has anti-nociception activity. Firstly, β-Endorphin combines together with the opioid receptors in hyperalgesia. Further, β-Endorphin suppresses the release of substance P at the level of spinal cord and blocks the conduction of pain on the primary sensory neurons. Moreover, β-Endorphin activates the endogenous analgesia system located in the CNS. In addition, β-Endorphin inhibits the conduction of pain and agitation of nociceptors to exert an analgesic effect[2].

分子量

3464.98

性状

Solid

Formula

C158H251N39O46S

CAS 号

61214-51-5

Sequence

Tyr-Gly-Gly-Phe-Met-Thr-Ser-Glu-Lys-Ser-Gln-Thr-Pro-Leu-Val-Thr-Leu-Phe-Lys-Asn-Ala-Ile-Ile-Lys-Asn-Ala-Tyr-Lys-Lys-Gly-Glu

Sequence Shortening

YGGFMTSEKSQTPLVTLFKNAIIKNAYKKGE

中文名称

β-内啡肽,人

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture

Powder-80°C2 years
-20°C1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)