CAS NO: | 156053-89-3 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | Alvimopan (ADL 8-2698) is a potent, selective, orally active and reversibleμ-opioid receptorantagonist, with anIC50of 1.7 nM. Alvimopan has selectivity for μ-opioid receptor (Ki=0.47 nM) overκ-andδ-opioid receptors(Kis=100, 12 nM, respectively). Alvimopan can be used for the research of postoperative ileus[1][2][3]. |
IC50& Target | IC50: 1.7 nM (μ-opioid receptor)[1] |
体外研究 (In Vitro) | Alvimopan inhibits the loperamide-stimulated [35S]GTPγS binding to membranes containing the cloned human μ-opioid receptor, with an IC50value of 1.7 nM[1]. |
体内研究 (In Vivo) | Alvimopan (0.1-1.0 mg/kg; p.o.) partially antagonizes the slowing of small intestinal transit of113Sn-labelled microspheres produced by morphine in rats[3]. |
Clinical Trial | |
分子量 | 424.53 |
Formula | C25H32N2O4 |
CAS 号 | 156053-89-3 |
中文名称 | 爱维莫潘;阿维莫泮;爱维莫泮 |
运输条件 | Room temperature in continental US; may vary elsewhere. |
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |