您好,欢迎来到试剂信息网! [登录] [免费注册]
试剂信息网
位置:首页 > 产品库 > BMS-986121
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
BMS-986121
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
BMS-986121图片
CAS NO:313671-26-0
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
BMS-986121 是μ opioid receptor的正变构调节剂 (PAM) 来自专利 WO2014107344。BMS-986121 是建立在一个化学支架上,代表了 μ 受体 PAMs 的一种新的化学类型。
生物活性

BMS-986121 is a positive allosteric modulator (PAM) of theμopioid receptorextracted from patent WO2014107344. BMS-986121 is built on a chemical scaffold representing a new chemotype for μ receptor PAMs[1][2][3].

IC50& Target

μ Opioid Receptor[1][3]

体外研究
(In Vitro)

BMS-986121 (1 μM~1 mM) significantly augments the β-arrestin–recruitment response produced by a low concentration of endomorphin-I (PAM-detection mode). BMS-986121 significantly increases the inhibition of forskolin-stimulated adenylyl cyclase activity produced by a ~EC10(30 pM) concentration of endomorphin-I in CHOμ cells. BMS-986121 (100 μM) produces leftward shifts in the potency of endomorphin-I (fourfold), morphine (fivefold), and leu-enkephalin (sixfold), in inhibition of forskolin-stimulated cAMP-accumulation assays in CHO-μ cells[1].

分子量

366.22

Formula

C15H9Cl2N3O2S

CAS 号

313671-26-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.