CAS NO: | 82824-01-9 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | Naloxonazine is a potent and selective opiate mu-1 antagonist that can also affectleishmaniaby regulating host coding function[1]. |
体外研究 (In Vitro) | Naloxonazine(0-50 μM, 24-72 h) 对细胞内Leishmania donovani的无鞭毛体阶段具有抑制活性,其最大抑制浓度 GI50为3.45 μM。而对 THP-1 宿主细胞的 GI50为 34 μM[1]。 |
体内研究 (In Vivo) | Naloxonazine (0-15 mg/kg, i.p., 20 h)在雄性 Wistar大鼠中,当剂量为 15 mg/kg 时,(olfactory discriminative stimulus)S+/CS+ 相关反应显著降低约 55%,由 14.63 降至 6.82。而在(olfactory stimulus)S-/CS-刺激条件下观察到更大的行为抑制,反应率降低 66%,从 9.00 降至 3.00[2]。 |
分子量 | 650.76 |
Formula | C38H42N4O6 |
CAS 号 | 82824-01-9 |
运输条件 | Room temperature in continental US; may vary elsewhere. |
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |