您好,欢迎来到试剂信息网! [登录] [免费注册]
试剂信息网
位置:首页 > 产品库 > Carprofen
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Carprofen
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Carprofen图片
CAS NO:53716-49-7
规格:≥98%
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议
1g电议
2g电议
5g电议
10g电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)273.71
FormulaC15 H12ClNO2
CAS No.53716-49-7
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 55 mg/mL (200.9 mM)
Water: <1 mg/mL
Ethanol: 55 mg/mL (200.9 mM)
Other infoChemical Name: 2-(6-chloro-9H-carbazol-2-yl)propanoic acid
InChi Key: PUXBGTOOZJQSKH-UHFFFAOYSA-N
InChi Code: InChI=1S/C15H12ClNO2/c1-8(15(18)19)9-2-4-11-12-7-10(16)3-5-13(12)17-14(11)6-9/h2-8,17H,1H3,(H,18,19)
SMILES Code: CC(C1=CC2=C(C=C1)C3=C(N2)C=CC(=C3)Cl)C(=O)O
SynonymsRo205720; C-5720; Ro 205720; C5720; Carprofen; Imadyl; Rimadyl; Ridamyl; Ro 20-5720; C 5720; Imadyl; quellin; Novox; Imafen; Rovera
实验参考方法
In Vitro

In vitro activity: Carprofen (S and R stereoisomers) inhibits canine COX2 with IC50 of 0.102 microM for the racemic mixture, the inhibition is primarily attributable to the S enantiomer (IC50, 0.0371 microM), which is approximately 200-fold more potent than the R enantiomer (IC50, 5.97 microM). Carprofen binds to human serum albumin (HSA) by both fluorescence and equilibrium dialysis (ED) methods is characterized by two sets of association constants [K1 = 5.1 μM (fluorescence) and 3.7 μM (ED), K2 = 37 μM (fluorescence) and 13 μM (ED)]. Carprofen primarily binds to site II, the benzodiazepine site, while the low affinity site of carprofen is site I, the warfarin site, the carboxyl group of carprofen is found to play an important role especially in the high affinity binding of carprofen to HSA.


Cell Assay: Cruciate ligament cells are used and incubated with DMEM supplemented with 10% FCS for 24 hours to synchronize cell cycles. The cell cultures are then preincubated without (control) or with a nonselective COX inhibitor (acetylsalicylic acid) or a preferential COX-2 inhibitor (Carprofen, meloxicam, or robenacoxib) to ssess whether NSAIDs prevented apoptosis when the cells are subsequently incubated with SNP. For all cell cultures except those designated as controls, 1 of 3 concentrations of 1 of the 4 NSAIDs (10, 100, or 200 μg of acetylsalicylic acid/mL; 0.1, 1, or 10 μg of Carprofend/mL; 0.1, 1, or 10 μg of meloxicame/mL; or 0.1, 1, or 10 μg of robenacoxibf/mL) is added to the culture media of each cell culture, and the cells are incubated for 2 hours.

In VivoCarprofen preoperatively has lower pain scores than the other groups, significantly so at 2 hours postextubation in the dogs. Carprofen (4 mg/kg) results in significant higher maximum plasma concentration, the area under the curve to the last data point, and area under the first moment curve up to the last data point in dogs. Carprofen (4 mg/kg) provides slightly better pain relief than pethidine and produced less sedation in dogs. Carprofen provides good analgesia during the 18 hours the dogs are in hospital and no adverse side effects are observed. Carprofen substantially increases the speed of lame birds, providing evidence that birds with moderate lameness suffer pain when they walk.
Animal modelDogs
Formulation & DosageEach dog receives Carprofen (2.2 mg/kg, PO, q 12 h), deracoxib (2 mg/kg, PO, q 24 h), or etodolac (10 to 15 mg/kg, PO, q 24 h) for 10 days in a crossover design with a 30- to 60-day washout period between treatments. On days 0, 3, and 10 of each treatment period, blood is collected for evaluation of TXB2 and PGE2 concentrations. In addition, anesthesia is induced with propofol (4 mg/kg) and maintained with isoflurane. Synovial fluid is collected from both stifle joints by use of a standard arthrocentesis technique for evaluation of PGE2 concentrations. Gastroscopy is performed during each anesthetic episode, and 3 to 6 endoscopic biopsy specimens are collected from the gastric antrum for evaluation of PGE1 and PGE2 synthesis. On day 0 for each dog, a gastric biopsy specimen is placed into a Campylobacter-like organism test kit and evaluated for up to 24 hours for Helicobacter spp. Stained slides (H&E) of gastric biopsy specimens are also evaluated for the presence of underlying inflammation
ReferencesAm J Vet Res. 1998 Nov;59(11):1441-6; Vet Surg. 1998 Nov-Dec;27(6):568-82; Am J Vet Res. 2005 May;66(5):812-7.