2-Furoyl-LIGRLO-amide TFA is a potent and selectiveproteinase-activated receptor 2 (PAR2)agonist with apD₂value of 7.0^[1][2]..

Proteinase-activated receptor 2 (PAR2)^[1]

2-Furoyl-LIGRLO-amide (2-Furoyl-LIGRLO-NH₂) is equally effective to and 10 to 25 times more potent than SLIGRLNH₂for increasing intracellular calcium in cultured human and rat PAR2-expressing cells, respectively^[1].
In bioassays of tissue PAR2 activity, measured as arterial vasodilation and hyperpolarization, 2-Furoyl-LIGRLO-amide (2-Furoyl-LIGRLO-NH₂) is 10 to 300 times more potent than SLIGRL-NH₂. Unlike trans-cinnamoyl-LIGRLO-NH₂, 2-Furoyl-LIGRLO-amide do not cause a prominent non-PAR2-mediated contraction of murine femoral arteries^[1].

Furoyl-LIGRLO-amide TFA (injected intradermally at the nape of the neck; 10 μg; pre-injected) exhibits fewer scratches in response to 2-Furoyl-LIGRLO-amide but not to histamine in Trpv3^-/-mice. But it decreases significantly the number of scratches in WT mice^[3].

891.98

C₃₈H₆₄F₃N₁₁O₁₀

{Fur-2-oyl}-Leu-Ile-Gly-Arg-Leu-{Orn}-NH2

{Fur-2-oyl}-LIGRL-{Orn}-NH2

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.