CAS NO: | 1478712-37-6 |
包装 | 价格(元) |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
生物活性 | BMS-986120 is a first-in-class oral and reversibleprotease-activated receptor4 (PAR4) antagonist, withIC50sof 9.5 nM and 2.1 nM in human and monkey blood, respectively. BMS-986120 has potent and selective antiplatelet effects[1][2]. | ||||||||||||||||
IC50& Target | IC50: 9.5 nM (PAR4, human), 2.1 nM (PAR4, monkey)[1] | ||||||||||||||||
体外研究 (In Vitro) | BMS-986120 has high binding affinity to PAR4 expressed on HEK293 cells and inhibition of PAR4-induced calcium mobilization with an IC50of 0.56 nM[3]. | ||||||||||||||||
体内研究 (In Vivo) | In monkeys, BMS (1 mg/kg) does not inhibit PA induced by PAR1-AP, ADP and collagen, supporting selectivity. BMS (0.2, 0.5, 1 mg/kg) reduces TW by 35±5, 49±4, and 83±4%, respectively. Maximum KBT and MBT increases are only 2.2-fold and 1.8-fold, respectively[1]. | ||||||||||||||||
Clinical Trial | |||||||||||||||||
分子量 | 513.59 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C23H23N5O5S2 | ||||||||||||||||
CAS 号 | 1478712-37-6 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 3.33 mg/mL(6.48 mM;ultrasonic and warming and heat to 80℃) 配制储备液
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