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tcY-NH2
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
tcY-NH2图片
CAS NO:327177-34-4
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
(trans-Cinnamoyl)-YPGKF-NH2
产品介绍
tcY-NH2 ((trans-Cinnamoyl)-YPGKF-NH2) 是一种有效的PAR4选择性肽类拮抗剂。tcY-NH2 抑制凝血酶和 AY-NH2诱导的血小板聚集和内皮抑素释放,可用于炎症、免疫学的研究。
生物活性

tcY-NH2 ((trans-Cinnamoyl)-YPGKF-NH2) is a potent selectivePAR4antagonist peptide. tcY-NH2 inhibits thrombin- and AY-NH2-induced platelet aggregation and endostatin release, and can be used in the research of inflammation, immunology[1][2][6].

体外研究
(In Vitro)

tcY-NH2 (0-500 μM) inhibits AYPGKF-NH2(10 μM)-induced platelet (obtained from male albino Sprague–Dawley rats) aggregation, with an IC50value of 95 μM[1].
tcY-NH2 potently activates aorta relaxation (RA) and gastric (LM) contraction, with IC50values of 64 μM (RA) and 1 μM (LM)[1].
tcY-NH2 (Tc-YPGKF-NH2, 400 μM, 5 min) prevents endostatin release and platelet aggregation induced by thrombin or by AY-NH2[2].
tcY-NH2 (5 μM, 15 min) decreases infarct size (IS) by 51%, and increases recovery of ventricular function by 26% in an isolated heart model[5].

体内研究
(In Vivo)

tcY-NH2 (tail vein injection, 0.6 mg/kg for a single dose) alleviates liver injury in Brain death (BD) rat model, indicated by lower serum ALT/AST levels and better histomorphology[3].
tcY-NH2 (intraperitoneal injection, 0.6 mg/kg for a single dose) increases posttraumatic activation of CD4+Tregs within the draining lymph nodes in burn injury mice model[4].
tcY-NH2 (intrapleural injection, 40 ng/kg for a single dose) inhibits neutrophil recruitment in experimental inflammation in mice[6].

Animal Model:Brain death (BD) rat model[3]
Dosage:0.6 mg/kg for a single dose
Administration:Tail vein injection for a single dose
Result:Reduced blood platelet activation and hepatic platelet accumulation.
Attenuated the inflammatory response and apoptosis in the livers.
Inhibited the activation of NF-κB and MAPK pathways induced by Brain death (BD).
Animal Model:Burn injury model of C57BL/6 N mice[4]
Dosage:0.6 mg/kg for a single dose
Administration:Intraperitoneal injection
Result:Increased expression and phosphorylation of PKC-θ in the presence of platelets, without affecting early posttraumatic hemostasis.
Animal Model:BALB/c mice[6]
Dosage:40 ng/kg for a single dose
Administration:Intrapleural injection
Result:Abolished the number of rolling and adhering neutrophils on the vessel wall.
Inhibited CXCL8- and Cg-induced neutrophil migration into the pleural cavity of mice.
分子量

739.86

Formula

C40H49N7O7

CAS 号

327177-34-4

Sequence Shortening

{trans-Cinnamoyl}-YPGKF-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.