CAS NO: | 301177-43-5 |
包装 | 价格(元) |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | ESI-08 is a potent and selectiveEPACantagonist, which can completely inhibit bothEPAC1andEPAC2(IC50of 8.4 μM) activity. ESI-08 selectively blocks cAMP-inducedEPACactivation, but does not inhibit cAMP-mediatedPKAactivation[1]. | ||||||||||||||||
IC50& Target | IC50: 8.4 μM (EPAC2)[1] | ||||||||||||||||
体外研究 (In Vitro) | Exchange proteins directly activated by cAMP (EPAC) are a family of guanine nucleotide exchange factors that regulate a wide variety of intracellular processes in response to second messenger cAMP. ESI-08 at 25 μM has been found not to alter cAMP-induced type I and II PKA holoenzymes activation while H89, a selective PKA inhibitor, blocked the type I or II PKA activities completely[1]. | ||||||||||||||||
分子量 | 353.48 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C20H23N3OS | ||||||||||||||||
CAS 号 | 301177-43-5 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 | 4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) | ||||||||||||||||
溶解性数据 | In Vitro: DMSO : 100 mg/mL(282.90 mM;ultrasonic and warming and heat to 60℃) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |