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NSC 23766
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
NSC 23766图片
CAS NO:733767-34-5
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
NSC 23766 是特异性的可渗透细胞的Rac GTPase抑制剂,用于癌症研究。
生物活性

NSC 23766 is a cell-permeable, reversible and specific inhibitor ofRac GTPase, used forcancertreatment.

体外研究
(In Vitro)

NSC 23766 (100 μM) treatment effectively inhibits polar body emission in a dose-dependent manner. NSC 23766 (200 μM) increases the percentage of morphologically abnormal spindles of oocytes. In NSC 23766-treated oocytes, the p-MAPK protein expression is significantly decreased[2]. NSC23766 (50 μM) plus 100 ng/mL Jagged1, GDF9 and BMP15, reduces the number of germLine cell cysts and increases the number of primordial follicles[3]. NSC23766 significantly inhibits GTP-Rac1 activity and phosphorylation of Rac1-PAK, ERKs and p38 MAPK in the spinal dorsal horn neurons[4].

体内研究
(In Vivo)

NSC23766 (2.5 mg/kg/day, i.p.) significantly attenuates the onset of spontaneous diabetes in NOD mice, without significant effects on the growth (body weights) of the mice. NSC23766 significantly increases the expression of Rac1 and CHOP, a marker for ER-stress, in islets from NOD mice[1].

分子量

421.58

Formula

C24H35N7

CAS 号

733767-34-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.