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KRAS G12D inhibitor 14
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
KRAS G12D inhibitor 14图片
CAS NO:2765254-39-3
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
KRAS G12D inhibitor 14 是一种有效的KRAS G12D抑制剂,与 KRAS G12D蛋白结合的KD为 33 nM。KRAS G12D inhibitor 14 降低 KRAS G12D (KRAS G12D-GTP) 的活性形式,但不降低 KRAS G13D。
生物活性

KRAS G12D inhibitor 14 is a potentKRAS G12Dinhibitor with aKDof 33 nM for binding to KRAS G12D protein. KRAS G12D inhibitor 14 decreases the active form of KRAS G12D (KRAS G12D-GTP) but not KRAS G13D[1].

IC50& Target[1]

KRas G12D

33 nM (Kd)

体外研究
(In Vitro)

KRAS G12D inhibitor 14 (compound KD-8) shows antiproliferative activity with an IC50 of 2.1 μM against three KRAS G12D-mutated cells (Panc1, SW1990 and CT26). KRAS G12D inhibitor 14 decreases the active form of KRAS (KRAS-GTP) in KRAS G12D mutated cancer cell lines (CT26 and SW1990) but not in KRAS G13D mutated cancer cell lines (HCT116). KD-8 also causes efficient apoptosis of SW1990 and CT26 cancer cells. KRAS G12D inhibitor 14 down-regulates the phosphorylated Raf and Erk in CT26 and SW1990 cancer cell lines but not in HeLa cells (KRAS WT)[1].

体内研究
(In Vivo)

KRAS G12D inhibitor 14 (compound KD-8) (40 mg/kg or 60 mg/kg; i.p.) exhibits significant antitumor efficacy in a CT26 tumor model with a tumor growth inhibition (TGI) of 42% or 53% without causing apparent toxicity[1].

分子量

420.45

Formula

C20H19F3N4OS

CAS 号

2765254-39-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.