CAS NO: | 2561529-96-0 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | MRTX849 acid, a derivative of MRTX849, can be used in the synthesis ofPROTACLC-2 (HY-137516). LC-2 is a potent and first-in-classPROTACcapable of degrading endogenous KRAS G12C (DC50s between 0.25 and 0.76 μM)[1][2]. | |
IC50& Target[1] |
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体外研究 (In Vitro) | LC-2 induces degradation of endogenous KRASG12C in multiple KRAS mutant cancer cell (NCI-H2030, MIA PaCa-2, SW1573, NCI-H23 and NCI-H358 cells) with DC50s between 0.25 and 0.76 μM. LC-2-induced KRASG12C degradation occurs via abona fidePROTAC mechanism. MIA PaCa-2, NCI-H23, and SW1573 cells are treated with 2.5 μM of LC-2 for 6, 24, 48, and 72 h. In all three cell lines, maximal KRAS degradation occurred within 24 h and was sustained up to 72 h[1]. | |
分子量 | 662.15 | |
Formula | C34H37ClFN7O4 | |
CAS 号 | 2561529-96-0 | |
运输条件 | Room temperature in continental US; may vary elsewhere. | |
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |