d[Leu4,Lys8]-VP

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d[Leu4,Lys8]-VP

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

42061-33-6

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

D[LEU4,LYS8]-VP 是血管加压素V_1b受体的选择性激动剂，对大鼠，人类和小鼠V_1b受体的K_i值分别为 0.16 nM，0.52 nM 和 1.38 nM。D[LEU4,LYS8]-VP 具有较弱的抗利尿剂、升压药和体外催产素活性。

生物活性

D[LEU4,LYS8]-VP is a selective agonist ofvasopressin V_1breceptor, with theK_isof 0.16 nM, 0.52 nM, and 0.1.38 nM for rat, human and mouseV_1breceptor, respectively. D[LEU4,LYS8]-VP has weak antidiuretic, vasopressor, and in vitro oxytocic activities^[1]^[2].

IC₅₀& Target

vasopressin V_1breceptor^[1]

分子量

1026.23

Formula

C₄₇H₆₇N₁₁O₁₁S₂

CAS 号

42061-33-6

Sequence

{Mpa}-Tyr-Phe-Leu-Asn-Cys-Pro-Lys-Gly (Disulfide bridge:Mpa1-Cys6)

Sequence Shortening

{Mpa}-YFLNCPKG-NH2 (Disulfide bridge:Mpa1-Cys6)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

In Vitro:

H₂O

Peptide Solubility and Storage Guidelines:

1. Calculate the length of the peptide.

2. Calculate the overall charge of the entire peptide according to the following table:

	Contents	Assign value
Acidic amino acid	Asp (D), Glu (E), and the C-terminal -COOH.	-1
Basic amino acid	Arg (R), Lys (K), His (H), and the N-terminal -NH₂	+1
Neutral amino acid	Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q)	0

3. Recommended solution:

Overall charge of peptide	Details
Negative (<0)	1. Try to dissolve the peptide in water first. 2. If water fails, add NH₄OH (<50 μL). 3. If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0)	1. Try to dissolve the peptide in water first. 2. If water fails, try dissolving the peptide in a 10%-30% acetic acid solution. 3. If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0)	1. Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first. 2. For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.