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Glycerophosphoinositol choline
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Glycerophosphoinositol choline图片
CAS NO:425642-32-6
包装与价格：
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
甘油磷酸肌醇胆碱
产品介绍
Glycerophosphoinositol choline 是一种必需营养素，可激活 α7 烟碱受体 (alpha7 nicotinic receptors)，具有镇痛、抗炎活性。可影响肝脏疾病、动脉粥样硬化和神经系统疾病等疾病。
生物活性

Glycerophosphoinositol choline is an essential nutrient that activatesalpha7 nicotinic receptorsand has analgesic and anti-inflammatory activity. Glycerophosphoinositol choline can affect diseases such as liver disease, atherosclerosis and neurological disorders[1][2].

IC50& Target

Human Endogenous Metabolite

 

体外研究
(In Vitro)

Glycerophosphoinositol choline (0 or 70 μM, 4 days) can effectively mitigate apoptosis and maintain cell viability[1].

Cell Viability Assay[1]

Cell Line:Rat pheochromocytoma cells PC12
Concentration:0 or 70 μM
Incubation Time:4 days
Result:Showed the cell viability of 94% at 70 μM while cell viability of 83% at 0 μM.
Reduced the number of cells with DNA breaks (characteristic of apoptosis) by 8.5% at 70 μM compared to the no treatment group.
体内研究
(In Vivo)

Glycerophosphoinositol choline (s.c., 0.2 and 100 mg/kg/h, 24 or 48 hours) can reduce postoperative injurious reflexes and effectively decreases tumor necrosis factor (TNF) release from macrophages in female C57/Bl6 mice[2].

Animal Model:Postoperative pain model of female C57/Bl6 mice[2]
Dosage:0.2 and 100 mg/kg/h
Administration:Subcutaneous injection, 24 or 48 hours
Result:Reduced heat hypersensitivity after surgery with maximal efficacy after 48 h treatment and the ED50value of choline dose was 1.7 mg/kg/h.
Reduced hypersensitivity to punctate mechanical stimuli 48 hours after infusion in a dose-dependent manner and with the ED50value of 4.7 mg/kg/h but not 24 hours.
Clinical Trial
分子量

437.38

Formula

C14H32NO12P

CAS 号

425642-32-6

中文名称

甘油磷酸肌醇胆碱

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.