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P-gp inhibitor 4
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
P-gp inhibitor 4图片
CAS NO:2652001-05-1
包装与价格：
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
P-gp inhibitor 4 (Compound 8b) 是一种选择性的P-glycoprotein调节剂，EC50值为 94 nM。P-gp inhibitor 4 增加药物通过胃肠道屏障的能力，恢复 doxorubicin 在耐药癌细胞中的毒性。
生物活性

P-gp inhibitor 4 (Compound 8b) is a selectiveP-glycoproteinmodulator with anEC50of 94 nM. P-gp inhibitor 4 increases drug transport across gastro-intestinal barrier and recovers doxorubicin toxicity in multidrug resistantcancercells[1].

IC50& Target

EC50: 94 nM (P-glycoprotein)[1]

体外研究
(In Vitro)

P-gp inhibitor 4 (Compound 8b) (0-1 μM, 48 h) significantly increases the cytotoxic effect of antineoplastic drug with co-administration[1].
P-gp inhibitor 4 does not alter the physiological properties of Caco-2 cells barrier model[1].
P-gp inhibitor 4 selectively reduces the activity of P-gp and increases the transport of multiple P-gp substrates across gastro-intestinal barrier[1].

Cell Proliferation Assay[1]

Cell Line:MDCK-MDR1
Concentration:100 nM, 500 nM and 1 μM
Incubation Time:48 h
Result:Showed no cytotoxicity. Significantly increased the cytotoxic effect of antineoplastic drug.

Cell Viability Assay[1]

Cell Line:Caco-2 cells
Concentration:0.1 nM-100 μM
Incubation Time:72 h
Result:Displayed a dose-dependence cytotoxicity that was significant at ≥ 10 μM concentration. Did not reduce cell viability at 100 nM.
分子量

714.85

Formula

C38H38N2O8S2

CAS 号

2652001-05-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.