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Quinidine gluconic acid
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Quinidine gluconic acid图片
CAS NO:7054-25-3
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
Quinate 是一种抗心律失常剂。Quinate 是一种有效的、具有口服活性的、选择性的细胞色素 P450db (cytochrome P450db) 抑制剂,也是 K+通道 (K+channel) 的有效阻断剂,其IC50值为 19.9 μM,也可诱导凋亡。Quinate 也可用作疟疾的研究。
生物活性

Quinate is an antiarrhythmic agent. Quinate is a potent, orally active, selectivecytochrome P450dbinhibitor. Quinate is also aK+channelblocker with anIC50of 19.9 μM, and can induceapoptosis. Quinate can be used for malaria research[1][2][3][4].

体外研究
(In Vitro)

Quinate shows cytotoxicity against MES-SA cells, and induces apoptosis[4].

Cell Cytotoxicity Assay[4]

Cell Line:MES-SA and MESSA/DX5 cells
Concentration:10 μM
Incubation Time:24 hours
Result:Showed cytotoxicity against MES-SA cells in a concentration-dependent manner.

Apoptosis Analysis[4]

Cell Line:MES-SA and MESSA/DX5 cells
Concentration:10 μM
Incubation Time:24 hours
Result:Increased the apoptotic portion sub-G1 DNA contents induced by paclitaxel, while paclitaxel had no effect on sub-G1 DNA contents undergoing apoptosis.
体内研究
(In Vivo)

Quinate shows effects on the PTZ-induced seizure threshold[5].

Animal Model:Male mice of the NMRI strain (age 5-6 weeks and weight 25-30 g)[5]
Dosage:10, 20, and 30 mg/kg
Administration:Intraperitoneal injection; 10, 20, and 30 mg/kg; once
Result:Increased the threshold dose for the onset to tonic hind limb extension at a dose of 30 mg/kg, compared to the saline-treated control group (p<0.05).
Clinical Trial
分子量

520.57

Formula

C26H36N2O9

CAS 号

7054-25-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.