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Lamotrigine hydrate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Lamotrigine hydrate图片
CAS NO:375347-20-9
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
LTG hydrate
BW430C hydrate
产品介绍
Lamotrigine hydrate 是一种有效的,具有口服活性的抗惊厥或抗癫痫试剂 (anticonvulsant agent)。Lamotrigine hydrate 选择性地阻断电压门控钠离子通道 (Na+channels),稳定突触前神经元膜,抑制谷氨酸释放。Lamotrigine hydrate 可用于癫痫、局灶性癫痫等的研究。
生物活性

Lamotrigine hydrate is a potent and orally activeanticonvulsantor antiepileptic agent. Lamotrigine hydrate selectively blocks voltage-gatedNa+channels, stabilizing presynaptic neuronal membranes and inhibiting glutamate release. Lamotrigine hydrate can be used for the research of epilepsy, focal seizure, et al[1][2].

体外研究
(In Vitro)

Lamotrigine hydrate inhibits Veratrine evoked release of glutamate and aspartate with ED50values of 21 μM for both amino acids, but Lamotrigine hydrate is less potent in the inhibition of GABA release (ED50=44 μM. At concentrations up to 300 μM, LTG has no effect on patassium-evoked amino acid[1].
Lamotrigine hydrate is some five times less potent in the inhibition of Veratrine-evoked [3H]acetylcholine release (ED50=100 μM) than in glutamate or aspartate release[1].

体内研究
(In Vivo)

Lamotrigine hydrate (IP, 30 min before pentylenetetrazol; 10 mg/kg, 15 mg/kg or 20 mg/kg) decreases the seizure intensity at the higher doses, it increases the latency to the first pentylenetetrazol-induced seizure in all studied doses compared with the controls[2].

Clinical Trial
分子量

274.11

Formula

C9H9Cl2N5O

CAS 号

375347-20-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.