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PF 05089771 tosylate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
PF 05089771 tosylate图片
CAS NO:1430806-04-4
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
PF 05089771 tosylate 是有效的、具有口服活性的、选择性的Nav1.7丙烯酰胺抑制剂,其对 hNav1.7、cynNav1.7、dogNav1.7、ratNav1.7 和 musNav1.7 的IC50值分别为11 nM、12 nM、13 nM、171 nM 和 8 nM。PF 05089771 目前正用于疼痛和糖尿病神经性疾病的研究。
生物活性

PF 05089771 tosylate is a potent, orally active and selective arylsulfonamideNav1.7inhibitor, withIC50values of 11 nM, 12 nM, 13 nM, 171 nM and 8 nM for hNav1.7, cynNav1.7, dogNav1.7, ratNav1.7, and musNav1.7, respectively. PF 05089771 is under the study for pain and diabetic neuropathy[1][2].

IC50& Target

IC50: 11 nM (hNav1.7), 12 nM (cynNav1.7), 13 nM (dogNav1.7), 171 nM (ratNav1.7), 8 nM (musNav1.7)[1][2].

体外研究
(In Vitro)

PF-05089771 is determined to be more than 1000-fold selective over tetrodotoxin-resistant (TTX-R) Nav1.5 and Nav1.8 channels (IC50s >10 μM) and exhibited a range of selectivity over TTX-sensitive (TTX-S) channels (10-fold for Nav1.2 to 900-fold for Nav1.3 and Nav1.4)[1].
PF-05089771 (30 nM) blocks the majority of TTX-S current (75.5 ± 10.5%, n = 5) whilst 100 nM resulted in complete block[1].

Clinical Trial
分子量

672.56

Formula

C25H20Cl2FN5O6S3

CAS 号

1430806-04-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.