Olvanil

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Olvanil

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

58493-49-5

包装与价格：

包装	价格(元)
5mg	电议
10mg	电议
50mg	电议

产品名称

NE-19550
N-Vanillyloleamide

产品介绍

Olvanil (NE-19550) 是一种瞬时受体电位香草素受体亚型1 (TRPV1) 通道激动剂，EC₅₀为 0.7 nM，可用作缓解疼痛。

生物活性

Olvanil (NE-19550) is an analgesic and an agonist of transient receptor potential vanilloid type 1 (TRPV1) channels with anEC₅₀of 0.7 nM^[1].

IC₅₀& Target^[1]

TRPV1

0.7 nM (EC₅₀)

体外研究
(In Vitro)

Olvanil affects C6 glioma cell proliferation (IC₅₀ value of 5.5 μM)^[2]

体内研究
(In Vivo)

Olvanil is one capsaicin analog, which acts as an agonist at the vanilloid receptor. Olvanil may have causes an anxiogenic-like effect. Doses of 0, 0.2, 1.0 and 5.0 mg/kg Olvanil, respectively, yielded percent open arm entries at 5 min of 25±10.1, 19.3±7.1, 14.9±5.9 and 0±0^[3].

Animal Model:	Sprague-Dawley rats weighing approximately 200 g^[3]
Dosage:	0, 0.2, 1.0 and 5.0 mg/kg
Administration:	Injected intraperitoneally 30 min before the behavioral tests
Result:	The percent open arm times at 5 min were 12.9±8.1 for the 0 mg/kg dose, 8.9±4.2 for the 0.2 mg/kg dose, 15.2±7.9 for the 1 mg/kg dose and 0±0 for the 5 mg/kg dose. The mean number of entries into the closed arm at 5 min were 1.7±0.3, 3.3±0.8, 2.7±0.3 and 0.25±0.1 for doses of 0, 0.2, 1 and 5 mg/kg, respectively.

分子量

417.62

性状

Solid

Formula

C₂₆H₄₃NO₃

CAS 号

58493-49-5

中文名称

奥伐尼

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

溶解性数据

In Vitro:

DMSO : 100 mg/mL(239.45 mM;ultrasonic and warming and heat to 60℃)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	2.3945 mL	11.9726 mL	23.9452 mL
5 mM	0.4789 mL	2.3945 mL	4.7890 mL
10 mM	0.2395 mL	1.1973 mL	2.3945 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (stored under nitrogen)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。