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Fipronil-13C6
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Fipronil-13C6图片
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
Fipronil-13C6 是 13C 标记的Fipronil。Fipronil 是一种杀虫剂,可作为昆虫 GABA 受体的选择性拮抗剂 (对蟑螂和大鼠受体的 IC50s 分别为 30 nM 和 1,600 nM)。Fipronil 还抑制蟑螂神经元中谷氨酸盐引起的脱敏和非脱敏(IC50分别为 800 nM 和 10 nM)。在分离的大鼠肝微粒体中,Fipronil 诱导细胞色素 P450 (CYP) 亚型 CYP1A1/2,CYP2B1/2 和 CYP3A1/2 的活性。
生物活性

Fipronil-13C6 is the 13C-labeled Fipronil. Fipronil is an insecticide that acts as a selective antagonist of insect GABA receptors (IC50s = 30 nM and 1,600 nM for cockroach and rat receptors, respectively). Fipronil also inhibits desensitizing and non-desensitizing glutamate-induced chloride currents in cockroach neurons (IC50s = 800 nM and 10 nM, respectively). Fipronil induces activity of thecytochrome P450(CYP) isoforms CYP1A1/2, CYP2B1/2, and CYP3A1/2 in isolated rat liver microsomes.

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

分子量

443.10

Formula

C613C6H4Cl2F6N4OS

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.