CAS NO: | 1240425-05-1 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | Alvelestat (tosylate) is an orally bioavailable, affinity and selective inhibitor ofneutrophilelastase(NE)with apIC50value of 7.9 nM, aKivalue of 9.4 nM and aKdvalue of 9.5 nM[1]. |
IC50& Target | pIC: 7.9 nM; Ki: 9.4 nM; Kd: 9.5 nM (neutrophil elastas)[1] |
体外研究 (In Vitro) | Alvelestat (20 μg/mL; 16 hours; HBE and A549 cells) treatment decreases cells death and decreases the levels of IL-1β, IL-6, and TNF-α in vitro[2]. |
Clinical Trial | |
分子量 | 717.74 |
Formula | C32H30F3N5O7S2 |
CAS 号 | 1240425-05-1 |
运输条件 | Room temperature in continental US; may vary elsewhere. |
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |