AMG-1694 is a potentglucokinase–glucokinase regulatory protein (GK-GKRP)disruptors and promotes the dissociation of the GK-GKRP complex with anIC₅₀of 7 nM, indirectly increasing GK enzymatic activity. AMG-1694 potently reverses the inhibitory effect of GKRP on GK activity and promotes GK translocation. AMG-1694 normalizes blood glucose levels in several rodent models of diabetes and lowes blood glucose restricted to diabetic and not normoglycaemicanimals^[1].

IC50: 7 nM (GK-GKRP)^[1]

AMG-1694 is highly effective in restoring the enzymatic activity of GK with an EC₅₀of 0.020 μM in the presence of GKRP^[1].

533.63

C₂₃H₃₀F₃N₃O₄S₂

1361217-07-3

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.