JKE-1716

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JKE-1716

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2421118-05-8

包装与价格：

包装	价格(元)
1mg	电议
5mg	电议
10mg	电议
50mg	电议

产品介绍

JKE-1716 是一种强效选择性含硝酸GPX4抑制剂。JKE-1716 可以通过共价GPX4抑制选择性诱导ferroptosis。

生物活性

JKE-1716 is a potent and selective nitrolic acid-containingGPX4inhibitor. JKE-1716 is able of inducingferroptosisselectively through covalentGPX4inhibition^[1].

IC₅₀& Target

GPX4^[1]; Ferroptosis^[1]

体外研究
(In Vitro)

JKE-1716 (0~100 nΜ; 72 hours; LOX-IMVI cells) inhibits cell viability^[1].
JKE-1716 (LOX-IMVI cells) inhibits the expression of α-GPX4^[1].

Cell Viability Assay^[1]

Cell Line:	LOX-IMVI cells
Concentration:	0~100 nΜ
Incubation Time:	72 hours
Result:	Inhibited cell viability.

分子量

451.30

Formula

C₂₀H₂₀Cl₂N₄O₄

CAS 号

2421118-05-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.