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Atorvastatin hemicalcium trihydrate
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Atorvastatin hemicalcium trihydrate图片
CAS NO:344920-08-7
包装与价格：
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
阿托伐他汀半钙三水合物；阿托他伐汀半钙三水合物
产品介绍
Atorvastatin hemicalcium trihydrate 是一种具有口服活性的HMG-CoA还原酶抑制剂，具有有效降低血脂的能力。Atorvastatin hemicalcium trihydrate 以IC50值分别为 0.39 μM 和 2.39 μM 来抑制人 SV-SMC 细胞的增殖和侵袭。
生物活性

Atorvastatin hemicalcium trihydrate is an orally activeHMG-CoAreductase inhibitor, has the ability to effectively decrease blood lipids. Atorvastatin hemicalcium trihydrate inhibits human SV-SMC proliferation and invasion withIC50s of 0.39 μM and 2.39 μM, respectively[1][2][3].

体外研究
(In Vitro)

Atorvastatin hemicalcium trihydrate treatment decreases apoptosis of myocardial cells by down-regulating GRP78, caspase-12 and CHOP expression in myocardial cells after myocardial infarction, and the endoplasmic reticulum (ER) stress is activated in response to heart failure and angiotensin II (Ang II) stimulation[4].

体内研究
(In Vivo)

Atorvastatin (20-30 mg/kg; oral gavage; once a day; for 28 days; ApoE–/–mice) hemicalcium trihydrate treatment significantly reduces endoplasmic reticulum (ER) stress signaling proteins, the number of apoptotic cells, and the activation of Caspase12 and Bax in the Ang II-induced ApoE-/- mice. Proinflammatory cytokines such as IL-6, IL-8, IL-1β are all remarkably inhibited after Atorvastatin treatment[5].

Animal Model:Forty 8-week-old ApoE–/–mice induced with angiotensin II (Ang II)[5]
Dosage:20 mg/kg, 30 mg/kg
Administration:Oral gavage; once a day; for 28 days
Result:Significantly reduced ER stress signaling proteins, the number of apoptotic cells, and the activation of Caspase12 and Bax in the Ang II-induced ApoE–/–mice. Proinflammatory cytokines such as IL-6, IL-8, IL-1β were all remarkably inhibited.
Clinical Trial
分子量

632.73

Formula

C33H35FN2O5.1/2Ca.3H2O

CAS 号

344920-08-7

中文名称

阿托伐他汀半钙三水合物；阿托他伐汀半钙三水合物

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.