IDO1-IN-7 is a highly potent and selectiveindoleamine-2,3-dioxygenase-1 (IDO1)inhibitor, with an IC₅₀of 6.1 nM in in the cellular assay (SKOV3). IDO1-IN-7 has immunomodulatory effects. IDO1-IN-7 can be used for the research ofcancer^[1].

IC50: 6.1 nM (IDO1, SKOV3 cells)^[1]

IDO1-IN-7 exhibits moderate potency in a human whole blood assay with an IC₅₀of 330 nM^[1].
IDO1-IN-7 shows a favorable profile such as good metabolic stability and acceptable off-target selectivity^[1].
IDO1-IN-7 shows a high selectivity for IDO1 over tryptophan 2,3-dioxygenase (TDO) (IC₅₀=14,000 nM)^[1].

IDO1-IN-7 (10 mg/kg; p.o.) shows C_max=10.0 μM, AUC_{0-8 h}=27.1 μM*h, t_1/2=1.4 h in mouse^[1].

427.86

C₂₂H₁₉ClFN₃O₃

2351199-98-7

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.