CAS NO: | 118569-21-4 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | Zileuton sodium (A 64077 sodium) is a potent and selective inhibitor of5-lipoxygenase, exhibiting inflammatory activities. | |
IC50& Target |
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体外研究 (In Vitro) | In anti-CD3-treated cells, IL-2 decreases in Zileuton sodium (A 64077 sodium)-treated and untreated cells with increasing incubation time. Zileuton sodium (A 64077 sodium) likely reduces IL-2 levels by inhibiting 5-lipoxygenase, hence leukotriene B4 production, an IL-2 inducer[2]. | |
体内研究 (In Vivo) | In Zileuton sodium (A 64077 sodium) (5 mg/kg, p.o.) treated I/R rat, the effect of Zileuton to decrease NF-κB expression does not change significantly in the presence of COX inhibitors, and the group reveals significantly lower level of NF-κB staining. Zileuton (5 mg/kg, p.o.) treatment given to I/R rats decreases apoptotic index significantly. Zileuton has no significant effect on increased serum TNF-α levels in I/R group[1]. | |
Clinical Trial | ||
分子量 | 258.27 | |
Formula | C11H11N2NaO2S | |
CAS 号 | 118569-21-4 | |
中文名称 | 齐留通钠盐 | |
运输条件 | Room temperature in continental US; may vary elsewhere. | |
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |