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Zileuton sodium
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Zileuton sodium图片
CAS NO:118569-21-4
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
齐留通钠盐
A 64077 sodium
Abbott 64077 sodium
产品介绍
Zileuton sodium (A 64077 sodium) 是一种有效的,选择性的5-lipoxygenase抑制剂,具有抗炎的作用。
生物活性

Zileuton sodium (A 64077 sodium) is a potent and selective inhibitor of5-lipoxygenase, exhibiting inflammatory activities.

IC50& Target

5-Lipoxygenase

 

体外研究
(In Vitro)

In anti-CD3-treated cells, IL-2 decreases in Zileuton sodium (A 64077 sodium)-treated and untreated cells with increasing incubation time. Zileuton sodium (A 64077 sodium) likely reduces IL-2 levels by inhibiting 5-lipoxygenase, hence leukotriene B4 production, an IL-2 inducer[2].

体内研究
(In Vivo)

In Zileuton sodium (A 64077 sodium) (5 mg/kg, p.o.) treated I/R rat, the effect of Zileuton to decrease NF-κB expression does not change significantly in the presence of COX inhibitors, and the group reveals significantly lower level of NF-κB staining. Zileuton (5 mg/kg, p.o.) treatment given to I/R rats decreases apoptotic index significantly. Zileuton has no significant effect on increased serum TNF-α levels in I/R group[1].
Zileuton sodium (A 64077 sodium) (1200 mg/kg) inhibits the polyp formation in APCΔ468colon and small intestine. Zileuton treatment inhibits the proliferation rates of non epithelial cells in polyps, and increases the apoptosis rates in polyps in rat. There is significant increase in the number of apoptotic cells in the Zileuton-treated cells both in small intestine and in the colon. The reduced proliferation rate may significantly contribute to the reduction of polyposis in both the small intestine and colon of Zileuton-fed APCΔ468mice[3].

Clinical Trial
分子量

258.27

Formula

C11H11N2NaO2S

CAS 号

118569-21-4

中文名称

齐留通钠盐

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.