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24(S)-Hydroxycholesterol
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
24(S)-Hydroxycholesterol图片
CAS NO:474-73-7
包装:10mg
市场价:12000元

产品名称
24S-OHC
24S-HC
Cerebrosterol
产品介绍
24(S)-Hydroxycholesterol (24S-OHC) 是脑胆固醇的主要代谢物,对维持脑内胆固醇的稳态起主要作用。24(S)-Hydroxycholesterol (24S-OHC) 是非常有效的内源性的LXR的激动剂,在大脑和循环系统中含量高。24(S)-Hydroxycholesterol (24S-OHC) 是有效直接的、选择性的NMDARs的阳性变构调节剂,其机制不会与其它异构调节因子重叠。
生物活性

24(S)-Hydroxycholesterol (24S-OHC), the major braincholesterolmetabolite, plays an important role to maintain homeostasis ofcholesterolin the brain. 24(S)-Hydroxycholesterol (24S-OHC) is one of the most efficient endogenousLXRagonist known and is present in the brain and in the circulation at relatively high levels. 24(S)-Hydroxycholesterol (24S-OHC) is a very potent, direct, and selective positive allosteric modulator ofNMDARswith a mechanism that does not overlapthat of other allosteric modulators[1][2][3].

IC50& Target

NMDA Receptor

 

Human Endogenous Metabolite

 

分子量

400.68

性状

Solid

Formula

C28H48O

CAS 号

474-73-7

结构分类
  • Steroids
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder-20°C3 years
In solvent-80°C6 months
-20°C1 month