CAS NO: | 775351-65-0 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | Imeglimin (EMD 387008) is an oral glucose-lowering agent. Imeglimin improvesinsulinsensitivity. Imeglimin also reducesreactive oxygen species(ROS) production, increases mitochondrial DNA and improvesmitochondrialfunction[1]. | ||||||||
IC50& Target | ROS; mitochondrial function[1] | ||||||||
体外研究 (In Vitro) | Preincubation with Imeglimin (10 mM for 4 h or 100 μM for 24 h) fully prevents tert-butylhydroperoxide (tBH)-induced cell death[2]. Cell Viability Assay[2]
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体内研究 (In Vivo) | Imeglimin (200 mg/kg b.i.d. by oral gavage during the last 6 weeks of HFHSD feeding) significantly decreases hyperglycemia, restores normal glucose tolerance, and improves insulin sensitivity[1].
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Clinical Trial | |||||||||
分子量 | 155.20 | ||||||||
Formula | C6H13N5 | ||||||||
CAS 号 | 775351-65-0 | ||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |