CAS NO: | 230961-08-7 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
1mg | 电议 |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
生物活性 | UK 356618 (Compound 4j) is a potent and selective inhibitor ofmatrix metalloprotease-3 (MMP-3)with anIC50of 5.9 nM. UK 356618 is less potent againstMMP-1,MMP-2,MMP-9,MMP-13andMMP-14compared withMMP-3[1]. | ||||||||||||||||
IC50& Target[1][2] |
| ||||||||||||||||
体外研究 (In Vitro) | Inhibition of MMP-3 and selectivity over MMP-2 was remarkably sensitive to the size of the substituent and is clearly optimal for a methyl group (UK 356618, compound 4j). UK 356618 is more widely profiled against other MMPs[1]. | ||||||||||||||||
体内研究 (In Vivo) | UK 356618 (15 mg/kg; intravenous injection; for 24 h or 7 days; male Wistar rats) treatment at reperfusion significantly reduces MMP3 activity in the brain[3].
| ||||||||||||||||
分子量 | 557.72 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C34H43N3O4 | ||||||||||||||||
CAS 号 | 230961-08-7 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
| ||||||||||||||||
溶解性数据 | In Vitro: DMSO : 25 mg/mL(44.83 mM;Need ultrasonic and warming) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |