CAS NO: | 820223-77-6 |
包装 | 价格(元) |
1mg | 电议 |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
生物活性 | PF-00356231 hydrochloride is a specific, non-peptidic, non-zinc chelating ligand and inhibitor of matrix metalloproteinaseMMP-12(IC50=1.4 μM). PF-00356231 hydrochloride binds toMMP-12and forms PF-00356231/MMP-12 complex. PF-00356231 hydrochloride shows potency againstMMP-13,MMP-8,MMP-9,MMP-3withIC50s of 0.00065, 1.7, 0.98, 0.39 μM, respectively[1]. | ||||||||||||||||
IC50& Target[1] |
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体外研究 (In Vitro) | PF-00356231 hydrochloride against MMP-12/13 can be affected significantly by the presence of acetohydroxamate (AH). PF-00356231 hydrochloride decreases the IC50values of MMP-12 (0.014 μM) and MMP-13 (0.27 μM) in the presence AH[1]. | ||||||||||||||||
分子量 | 464.96 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C25H21ClN2O3S | ||||||||||||||||
CAS 号 | 820223-77-6 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 | 4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) | ||||||||||||||||
溶解性数据 | In Vitro: DMSO : 20.83 mg/mL(44.80 mM;ultrasonic and warming and heat to 60℃) H2O :< 0.1 mg/mL (ultrasonic;warming;heat to 60℃)(insoluble) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |