(R)-ND-336

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(R)-ND-336

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2252493-33-5

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

(R)-ND-336 是一种有效的选择性MMP-9抑制剂，K_i为 19 nM。(R)-ND-336 抑制 MMP-2 (K_i=127 nM) 和 MMP-14 (K_i=119 nM)。(R)-ND-336 具有用于糖尿病足溃疡 (DFUs) 研究的潜力。

生物活性

(R)-ND-336 is a potent and selectiveMMP-9inhibitor with aK_iof 19 nM. (R)-ND-336 inhibitsMMP-2(K_i=127 nM) andMMP-14(K_i=119 nM). (R)-ND-336 has the potential for diabetic foot ulcers (DFUs) research^[1].

IC₅₀& Target^[1]

MMP-9

19 nM (Ki)

MMP-2

127 nM (Ki)

MMP-14

119 nM (Ki)

体外研究
(In Vitro)

(R)-ND-336 poorly inhibits other MMPs (K_i>100 μM). (R)-ND-336 has a long residence time (the time the inhibitor is bound to MMP-9, calculated as 1/k_off) of 300 min^[1].
A favorable IC50value of 143 μM afforded a therapeutic index (IC₅₀/K_ifor MMP-9) ratio of 7530, indicating that (R)-ND-336 is not cytotoxic^[1].

体内研究
(In Vivo)

(R)-ND-336 (50 μg/wound/day for 14 days) accelerates wound healing faster^[1].
(R)-ND-336 has an AUC of 1.3 μMomin after topical administration and 35 μMomin following intravenous dosing, for an AUC_top/AUC_ivratio of 3.7%, indicating minimal absorption after topical administration in db/db mice^[1].

Animal Model:	Female db/db mice (BKS.Cg-Dock7^m+/+Lepr^db/J, 8-weeks old, ~40 g body weight)^[1]
Dosage:	50 μg
Administration:	Wound; once a day for 14 days
Result:	Accelerated wound healing faster and showed complete inhibition of MMP-9.

分子量

371.90

Formula

C₁₆H₁₈ClNO₃S₂

CAS 号

2252493-33-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.