CAS NO: | 1176758-04-5 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
生物活性 | Otaplimastat (SP-8203), amatrix metalloproteinase (MMP)inhibitor, blocksN-methyl-D-aspartate (NMDA) receptor-mediated excitotoxicity in a competitive manner. Otaplimastat also exhibits anti-oxidant activity. Otaplimastat can be used for the research of brain ischemic injury[1][2][3]. | ||||||||||||||||
IC50& Target[1] |
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体外研究 (In Vitro) | Otaplimastat (87.5-350 μM; 20 min) protects neuronal cells against NMDA-induced cell death in a competitive manner[1]. | ||||||||||||||||
体内研究 (In Vivo) | Otaplimastat (10-20 mg/kg; i.p. 30 min before occlusion and 1 h after reperfusion) prevents ischemic neuronal death in the occlusion model of MCA[1].
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Clinical Trial | |||||||||||||||||
分子量 | 534.61 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C28H34N6O5 | ||||||||||||||||
CAS 号 | 1176758-04-5 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 100 mg/mL(187.05 mM;Need ultrasonic) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |