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K-7174
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
K-7174图片
CAS NO:191089-59-5
包装与价格：
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
K-7174 是具有口服活性的proteasome和GATA的抑制剂。K-7174 抑制细胞黏附。K-7174 诱导细胞凋亡。K-7174 具有抗肿瘤活性，可用于癌症的研究。
生物活性

K-7174 is an orally activeproteasomeandGATAinhibitor. K-7174 is acell adhesioninhibitor. K-7174 induces cellapoptosis. K-7174 shows antitumor activities, it can be used for the research ofcancer[1][2][3].

体外研究
(In Vitro)

K-7174 (10 μM; 1 h) inhibits the adhesion by VCAM-1 and its ligand[1].
K-7174 (1-30 μM; 1 h) dose-dependently suppresses the VCAM-1 expression with an IC50value of 14 μM[1].
K-7174 (1-30 μM; 1 h) dose-dependently suppresses the induction of VCAM-1 mRNA by TNFα with an IC50value of 9 μM[1].
K-7174 (10-20 μM; 24 h) dose-dependently rescues Epo production by Hep3B cells[2].
K-7174 (2.5-30 μM; 24 h) inhibits the binding activity of GATA[2].
K-7174 (0-25 μM; 72 h) inhibits MM cells growth and induces cell apoptosis[3].

Cell Viability Assay[3]

Cell Line:KMS12-BM, U266, and RPMI8226 cell lines
Concentration:0-25 μM
Incubation Time:72 h
Result:Inhibited MM cells growth.

Apoptosis Analysis[3]

Cell Line:KMS12-BM, U266, and RPMI8226 cell lines
Concentration:10 μM
Incubation Time:48 h
Result:Significantly increased apoptosis of MM cells with the increasing percentage of annexin-V-positive cells.
体内研究
(In Vivo)

K-7174 (30 mg/kg; i.p. once daily for 9 days) reverses the decreasing of hemoglobin concentrations and reticulocyte counts by IL-1β or TNF-α[2].
K-7174 (75 mg/kg; i.p. once daily for 14 days) inhibits the tumor growth in vivo[3].
K-7174 (50 mg/kg; p.o. once daily for 14 days) inhibits the tumor growth in vivo and shows a better effect than intraperitoneal injection[3].

Animal Model:ICR mice with IL-β or TNF-α injection[2]
Dosage:30 mg/kg
Administration:Intraperitoneal injection; 30 mg/kg once daily for 9 days
Result:Increased erythropoietin (Epo) production, reticulocyte counts, and hemoglobin (Hb) concentrations
Animal Model:NOD/SCID mice with murine xenograft[3]
Dosage:75 mg/kg
Administration:Intraperitoneal injection; once daily for 14 days
Result:Significantly decreased tumor volume, but showed a significant body weight reduction after 10 days.
Animal Model:NOD/SCID mice with murine xenograft[3]
Dosage:50 mg/kg
Administration:Oral gavage; once daily for 14 days
Result:Showed an anti-myeloma activity. Proved oral administration is more effective than intraperitoneal injection.
分子量

568.74

Formula

C33H48N2O6

CAS 号

191089-59-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.