AGN194204 (IRX4204) is an orally active and selectiveRXRagonist withK_dvalues 0.4 nM, 3.6 nM and 3.8 nM andEC₅₀s of 0.2 nM, 0.8 nM and 0.08 nM forRXRα,RXRβandRXRγ, respectively. AGN194204 is inactive against RAR. AGN194204 has anti-inflammatory and anticarcinogenic actions^[1][2].

AGN194204 (NRX194204; 0-100 nM; 24 hours; E, RAW cells) treatment blocks the ability of lipopolysaccharide and tumor necrosis factor-α to induce the release of nitric oxide and interleukin 6 and the degradation of IKBα in RAW264.7 macrophage-like cells^[1].
AGN194204 (NRX194204; 1 μM; 72 hours; SK-BR-3 human breast cancer cells) treatment induces apoptosis in breast cancer cells^[1].

AGN194204 (NRX194204; 30-60 mg/kg; oral administration; daily; for 15 weeks; female A/J mice) treatment significantly reduces the number and size of tumors on the surface of the lungs and reduces the total tumor volume per slide by 64% to 81% compared with the control group^[1].

352.51

Solid

C₂₄H₃₂O₂

220619-73-8

Room temperature in continental US; may vary elsewhere.