RORγt agonist 1 (compound 14) is a potent, orally bioavailableRORγtagonist with an EC₅₀of 20.8 nM. RORγt agonist 1 showes high metabolic stability, improved aqueous solubility and excellent mouse PK profile. RORγt agonist 1 is a potential candidate of RORγt agonist forcancer immunotherapy^[1].

EC50: 20.8 nM (RORγt)^[1]

RORγt agonist 1 shows high metabolic stability (t1/2 = 113 min) in mouse liver microsome and has improved aqueous solubility at pH 7.4^[1].

545.45

C₂₄H₁₇F₆NO₅S

2377378-89-5

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.