| CAS NO: | 169474-77-5 |
| 包装 | 价格(元) |
| 1mg | 电议 |
| 5mg | 电议 |
| 10mg | 电议 |
| Cas No. | 169474-77-5 |
| Canonical SMILES | CC(C)C(C=CC=C1C(C)C)=C1NC(NCC2(C3=CC=C(OP(O)(O)=O)C=C3)O[C@H](C)[C@@H](C)O2)=O |
| 分子式 | C25H35N2O7P |
| 分子量 | 506.53 |
| 溶解度 | Soluble in DMSO |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | FCE 28654 is a water soluble inhibitor of acylCoA: cholesterol acyltransferase (ACAT), weakly inhibiting ACAT in microsomes from rabbit aorta and intestine, and monkey liver, with IC50s of 2.55, 1.08 and 5.69 μM, respcetively. FCE 28654 is an inhibitor of ACAT, weakly inhibiting ACAT in microsomes from rabbit aorta and intestine, and monkey liver, with IC50s of 2.55, 1.08 and 5.69 μM, respcetively[1]. FCE 28654 (15 mg/kg, p.o.) dramatically decreases blood cholesterol and modifies the hepatic cholesterol pattern via enhancing the free/esterified cholesterol ratio, in hypercholesterolemic rats. FCE 28654 (100 mg/kg, p.o.) also reduces microsomal ACAT activity rat plasma[1]. [1]. A.Chiari, et al. Synthesis and pharmacological profile of FCE 28654: A water-soluble and injectable ACAT inhibitor. Bioorganic & Medicinal Chemistry Letters. 1995 Aug 3;5(15):1581-1586. |
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