WNK-IN-11-d3

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WNK-IN-11-d3

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2123483-49-6

包装与价格：

包装	价格(元)
5mg	电议
10mg	电议
50mg	电议
100mg	电议

产品介绍

WNK-IN-11 D3 是一种具有口服活性、选择性和强效的 With-No-Lysine (WNK) 激酶抑制剂。WNK-IN-11 D3 有效调节心血管稳态。

生物活性

WNK-IN-11 D3 is an orally active, selective and potent With-No-Lysine (WNK) kinase inhibitor. WNK-IN-11 D3 is effective at regulating cardiovascular homeostasis^[1].

IC₅₀& Target

WNK^[1]

体内研究
(In Vivo)

WNK-IN-11 D3 (1.5 mg/kg; p.o.) shows an improved rat PK profile, including lower clearance, improvement in absolute oral exposure, and a 2-fold improvement in oral bioavailability^[1].
WNK-IN-11 D3 (30 mg/kg; p.o.) shows significant reductions in systolic blood pressure (SBP) vs untreated mice^[1].
WNK-IN-11 D3 (0~100 mg/kg; p.o.) induces dose dependent diuresis, natriuresis, and kaliuresis, from 10 to 100 mg/kg^[1].
WNK-IN-11 D3 shows trends toward reduction of blood pressure, stroke volume, and total peripheral resistance, while increasing heart rate. WNK-IN-11 D3 shows efficacy in rodent models of hypertension and volume overload^[1].

Animal Model:	Sprague–Dawley rats^[1]
Dosage:	1.5 mg/kg
Administration:	P.o.
Result:	Showed an improved rat PK profile, including lower clearance, improvement in absolute oral exposure, and a 2-fold improvement in oral bioavailability.

Animal Model:	FVB mice^[1]
Dosage:	30 mg/kg
Administration:	P.o.
Result:	Showed significant reductions in systolic blood pressure (SBP) vs untreated mice.

Animal Model:	FVB mice^[1]
Dosage:	0~100 mg/kg
Administration:	P.o.
Result:	Induced dose dependent diuresis, natriuresis, and kaliuresis, from 10 to 100 mg/kg.

分子量

465.41

性状

Solid

Formula

C₂₁H₁₈D₃Cl₂N₅OS

CAS 号

2123483-49-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : ≥ 100 mg/mL(214.86 mM)

*"≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	2.1486 mL	10.7432 mL	21.4864 mL
5 mM	0.4297 mL	2.1486 mL	4.2973 mL
10 mM	0.2149 mL	1.0743 mL	2.1486 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。