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Mitochonic acid 5(MA-5)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Mitochonic acid 5(MA-5)图片
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
线粒体酸 5 (MA-5) 结合线粒体并改善肾小管和心肌细胞损伤。

Cell experiment:

The mouse BV-2 cells used in this study are cultured in L-DMEM supplemented with 10% fetal bovine serum (FBS) at 37℃ in an atmosphere with 5% CO2. To induce inflammatory injury, cells are treated with 10 ng/mL TNFα for about 12 h. Mitochonic acid 5 (0-10 μM) is incubated with BV-2 cells for about 12 h with TNFα treatment[2].

Animal experiment:

Mice[1]For evaluation of the blood concentrations of Mitochonic acid 5 (MA-5), Mitochonic acid 5 is orally administered at doses of 25, 50, or 150 mg/kg to C57/BL 6 mice, and blood samples are collected at the designated times. After 1 hour, the mice are euthanized. The blood concentration of Mitochonic acid 5 is determined by LC/MS/MS[1].

产品描述

Mitochonic acid 5 binds mitochondria and ameliorates renal tubular and cardiac myocyte damage. Mitochonic acid 5 modulates mitochondrial ATP synthesis.

Mitochonic acid 5 (MA-5) modulates mitochondrial ATP synthesis independently of oxidative phosphorylation and the electron transport chain. Mitochondrial dysfunction causes increased oxidative stress and depletion of ATP, which are involved in the etiology of a variety of renal diseases[1]. Mitochonic acid 5 (MA-5), which is derived from the plant growth hormone indole-3-acetic acid, can protect mitochondrial function by regulating energy metabolism and reducing mitochondrial oxidative stress. To observe the protective role of Mitochonic acid 5 in microglia under inflammatory conditions, TNFα is applied. Subsequently, the MTT assay is used to evaluate cell viability. In response to the TNFα treatment, cell viability significantly decreases. However, this effect is dose-dependently inhibited by Mitochonic acid 5 treatment[2].

Administration of Mitochonic acid 5 (MA-5) to an ischemia-reperfusion injury model and a cisplatin-induced nephropathy model improved renal function. To examine the tissue-protective effect of Mitochonic acid 5, the oral bioavailability is examined. Oral administration of Mitochonic acid 5 increases the plasma concentration in a dose-response manner at the peak time of 1 hour[1].

[1]. Suzuki T, et al. Mitochonic Acid 5 Binds Mitochondria and Ameliorates Renal Tubular and Cardiac Myocyte Damage. J Am Soc Nephrol. 2016 Jul;27(7):1925-32. [2]. Lei Q, et al. Mitochonic acid 5 activates the MAPK-ERK-yap signaling pathways to protect mouse microglial BV-2 cells against TNFα-induced apoptosis via increased Bnip3-related mitophagy. Cell Mol Biol Lett. 2018 Apr 5;23:14.