Selegiline

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Selegiline

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

14611-51-9

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品名称

司来吉兰
Deprenyl
(-)-Selegiline
(-)-Deprenyl

产品介绍

Selegiline (Deprenyl) 是一种有效、选择性和不可逆的MAO-B抑制剂，IC₅₀值为 51 nM。Selegiline 对 MAO-B 的选择性比 MAO-A 高 450 倍 (IC₅₀=23 μM)。Selegiline 可用于帕金森氏病、阿尔茨海默病和重度抑郁症的研究。

生物活性

Selegiline (Deprenyl) is a potent, selective and irreversible inhibitor ofMAO-B, with anIC₅₀of 51 nM. Selegiline exhibits 450-flod selectivity forMAO-BoverMAO-A(IC₅₀=23 μM). Selegiline can be used for the research of Parkinson's disease, Alzheimer's disease and major depressive disorder^[1]^[2]^[3].

IC₅₀& Target^[1]

MAO-B

51 nM (IC₅₀)

体外研究
(In Vitro)

Selegiline (1 nM-1 μM) inhibits recombinant human MAO-B in a concentration-dependent manner^[1].
Selegiline (10 mM) increases the efflux of norepinephrine (NE), dopamine (DA) and serotonin (5-HT) from the rat hypothalamus in vitro. Selegiline inhibits the efflux of dihydroxyphenylacetic acid (DOPAC) and 5-hydroxyindoleacetic acid (5-HIAA) in a dose-dependent manner^[3].

体内研究
(In Vivo)

Selegiline (1 mg/kg; i.p. daily for 24 days) reduces Cocaine self-administration of mice and does not affect Cocaine-caused body weight loss. Selegiline reduces 3,4-dihydroxyphenylacetic acid (DOPAC) and 5-hydroxyindoleacetic acid (5-HIAA) concentrations in frontal cortex^[4].

Animal Model:	Male C57BL/6J mice (20-22 g)^[4]
Dosage:	1 mg/kg
Administration:	I.p. daily for 24 days
Result:	Single injection did not acutely affect mouse locomotor activity. 14 consecutive days administration did not affect food reward. Reduced Cocaine self-administration, and reduced DOPAC and 5-HIAA concentrations in frontal cortex.

分子量

187.28

Formula

C₁₃H₁₇N

CAS 号

14611-51-9

中文名称

司来吉兰

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.