| CAS NO: | 72-48-0 |
| 包装 | 价格(元) |
| 100mg | 电议 |
| 25mg | 电议 |
| Cas No. | 72-48-0 |
| 别名 | 1,2-二羟基蒽醌 |
| 化学名 | 1,2-dihydroxyanthracene-9,10-dione |
| Canonical SMILES | O=C(C1=C2C(O)=C(O)C=C1)C3=CC=CC=C3C2=O |
| 分子式 | C14H8O4 |
| 分子量 | 240.21 |
| 溶解度 | DMF: 20 mg/ml,DMSO: 20 mg/ml,DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml,Ethanol: slightly soluble |
| 储存条件 | Store at RT |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Alizarin is an anthraquinone dye for detecting the presence of calcium salts [1]. Alizarin belongs to the anthraquinone group. It is a chelator for calcium and is commonly used to stain the calcifying or calcio-receptive zone of the collagenous matrix where calcium salts are being deposited. On the other hand, the Alizarin complexone is used for bone staining in vivo to study bone remodeling [1]. Alizarin is proved to have anti-tumor efficacy. It suppresses the cell growth of the prostate cancer, breast cancer and osteosarcoma cell lines in vitro. Among these, the osteosarcoma cells appear to be most sensitive. The IC50 values of Alizarin against three osteosarcoma cell lines Saos-2, MG-63 and U-2 OS are 27.5, 29 and 69.9μg/ml, respectively. Alizarin inhibits the cell growth through cell proliferation blockade rather than induction of apoptosis. It inhibits the phosphorylation of ERK. In addition, Alizarin is also found to induce S-phase arrest as well as a decrease of the G0/G1 and G2/M phases [1]. References: |
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